hVIVO plc·Healthcare
hVIVO plc operates as a pharmaceutical service and contract research company. The company is involved in testing vaccines and antivirals using human challenge clinical trials. It provides services to big pharma, biotech, government, and public health organizations. The company has a portfolio of human challenge study models for conditions, such as RSV, flu, human rhinovirus, asthma, malaria, cough, and COPD, as well as developing COVID-19 human challenge study model. In addition, the company is developing a database of infectious disease progression data that include Disease in Motion platform, which comprises unique datasets, such as clinical, immunological, virological, and digital (wearable) biomarkers. The Disease in Motion platform has various potential applications across a range of end users, including big technology, wearables, pharma, and biotech companies. Further, the company provides preclinical and early clinical research services; sales and marketing services; and biometry, data management, and statistics to its various European pharmaceutical clients, as well as drug development consultancy and services, including CMC (chemistry, manufacturing, and controls), and PK and medical writing to a range of European clients. The company was formerly known as Open Orphan Plc and changed its name to hVIVO plc in October 2022. hVIVO plc is headquartered in London, the United Kingdom.

hVIVO PLC (AIM:HVO), the human challenge trial specialist, will hold a capital markets day on 11 June in Canary Wharf as it seeks to reposition itself as a full-service early clinical development partner. The event will feature speakers from Boehringer Ingelheim, RA Capital, ILiAD Biotechnologies and Decoy Therapeutics, alongside hVIVO's own leadership team.

hVIVO PLC (AIM:HVO) chief executive, Yamin ‘Mo' Khan, talked with Proactive about the company's latest contract win with a new European biotech client for an influenza human challenge trial. Khan explained that the trial is set to begin almost immediately, with most of the revenue expected to be recognised in 2026 and additional contributions extending into 2027.

Shares in hVIVO PLC (AIM:HVO), the human challenge trial specialist, were up 7% to 7.99p, extending a recovery that has seen the stock gain around 25% since the start of the year, after the latest in a run of contract announcements. The catalyst for today's move is the signing of a £6 million clinical trial agreement to conduct an influenza human challenge trial for an unnamed biopharmaceutical company, the latest in a sequence of deals that analysts at Cavendish say is providing a "step change" to revenue visibility for 2026.

The signing of a pivotal phase III human challenge trial for a whooping cough vaccine marks a turning point not just for hVIVO PLC (AIM:HVO), but for the entire human challenge trial model as a credible route to regulatory approval. Until now, human challenge trials have largely been used in earlier-stage drug development, where exposing healthy volunteers to a pathogen under controlled conditions allows researchers to generate proof-of-concept efficacy data quickly and cheaply.

hVIVO PLC (AIM:HVO) chief executive, Yamin “Mo” Khan, talked with Proactive about the company's full-year results, highlighting financial performance, strategic progress and outlook for 2026. Khan explained that despite a challenging macroeconomic environment, the company delivered results in line with expectations, reporting revenue of just under £47 million and a positive EBITDA of over £1 million.

hVIVO plc (OPORF) Q4 2025 Earnings Call Transcript